Cancer Therapeutics Research

 
 

A. Pratap Kumar, Ph.D.  (Medicine/Urology) – The long-term objective of my research is to understand molecular and cellular mechanisms involved in development, progression and dissemination of prostate cancer using in vitro and in vivo pre-clinical animal models for potential translation to the bed side. Numerous cutting edge technologies including magnetic resonance imaging, chromatin immunoprecipitations, gene and proteomic array along with functional assays are routinely used in the laboratory to achieve these goals.





Susan Mooberry, Ph.D.  (Pharmacology) – Our research is dedicated to the discovery of more effective therapies for the treatment of cancer, primarily breast cancer. There are several aspects to our work including drug discovery, identification of the mechanisms of drug action, the nature of drug resistance, identifying rational drug combinations and elucidation of the signaling pathways by which anti-mitotic agents initiate mitotic arrest and apoptosis.





Thomas J. Slaga, Ph.D.  (Pharmacology) – The research in Dr. Slaga's laboratory is focused on glucocorticoid hormones (GC), very potent inhibitors of physiological DNA synthesis in keratinocytes in vivo. These hormones are also very effective in preventing carcinogen- and tumor promoter-induced skin hyperplasia, inflammation, and mouse skin tumor formation when applied to skin together with a carcinogen or a tumor promoter.





Jim Stockand, Ph.D.  (Physiology) – My laboratory uses a number of contemporary methodologies, including electrophysiology, molecular biology, biochemistry, genomics and proteomics, and fluorescence microscopy to investigate regulation of ENaC and aldosterone signaling. We routinely use yeast, bacteria, immortalized cell lines and animals in this regard.





Michael Wargovich, Ph.D.  (Molecular Medicine) – Our laboratory investigates ways to prevent colon cancer. Our focus is on the chemoprevention of cancer - “Chemoprevention” is a discipline of cancer research that is less than 20 years old and embraces the idea that cancer can be prevented or precancers can be inhibited from progressing to cancer by the use of natural compounds or pharmaceuticals.