PHARMACOLOGY FACULTY
Charles France
 
 
Selected Publications

Charles France

Maharaj Ticku Professor of Pharmacology
Professor of Psychiatry
Ph.D., University of Michigan

Office: 210-567-6969
Email: france@uthscsa.edu

 

View video introduction to Dr. France's lab

 

Keywords

drug abuse, opioids, benzodiazepines, GHB, drug discrimination, self administration, dependence, withdrawal, neuropharmacology

 

Research Summary

Research in the France laboratory focuses on interactions between behavior and pharmacology and how those interactions impact the abuse liability of drugs. One major goal is to understand how the subjective and other abuse-related effects of drugs change as a consequence of particular behavioral and pharmacologic histories. Behavioral procedures developed in this laboratory permit systemic investigation of drug dependence and withdrawal and ongoing studies examine how these phenomena can be modified by behavioral and pharmacologic interventions.

 

A unifying theme of research in the France laboratory is the application of receptor theory to the planning, execution, and interpretation of behavioral pharmacological studies. Thus, many of our studies examine differences in efficacy and selectivity among potential drugs of abuse and potential treatment compounds, thereby identifying the pharmacologic characteristics of drugs that are most important for specific behavioral effects (e.g., reinforcing effects).

 

Current areas of research include the following: the role of different monoamine systems in modifying the abuse and therapeutic effects of opioids; the impact of different diets on the abuse and therapeutic effects of drug acting on serotonin or dopamine systems; interactions between GHB and other "club drugs"; the role of insulin receptor pathways in regulating dopamine transporter activity and sensitivity to stimulants; GABA receptor heterogeneity and the dependence liability of sedative/hypnotics; and the influence of physical dependence on the reinforcing effects of opioids.


• Appointments, Boards, Committees and Memberships •

Councilor - American Society for Pharmacology and Experimental Therapeutics (ASPET) Governing Board - July, 2012


• Lab Personnel •

Dr. Lisa Gerak
Lisa Gerak, Ph.D.
Asst. Professor/Research
Dr. Gregory Collins
Gregory Collins, Ph.D.
Instructor/Research
Dr. David Maguire
David Maguire
Postdoctoral Fellow
Dr. Katherine Serafine
Katherine Serafine
Postdoctoral Fellow
Marlisa Burton
Marlisa Burton
Research Assistant











Andrew Lisenby
Andrew Lisenby
Research Assistant
Christopher Robinson
Christopher Robinson
Research Assistant
Crystal Taylor
Crystal Taylor
Research Assistant
Elise Rush
Elise Rush
Student Associate