Selected Publications
  • Loyd D, Weiss G, Henry M, Hargreaves KM. Serotonin Increases the Functional Activity of Capsaicin-sensitive Rat Trigeminal Nociceptors via Peripheral Serotonin Receptors. Pain (in press) 2011.
  • Scotland P, Belugin S, Henry M, Hargreaves KM, Goffin V, Akopian A. Endogenous Prolactin Generated by Inflammatory Conditions Contributes to Thermal Allodynia. Eur J Neurosci (in press) 2011.
  • Patil M, Patwardhan A, Salas M, Hargreaves KM, Akopian A. Cannabinoid Receptor Antagonists AM251 and AM630 Activate TRPA1 in Sensory Neurons. Neuropharmacology 61:778-88, 2011.
  • Ruparel N, Patwardhan A, Akopian A, Hargreaves KM. Desensitization of Transient Receptor Potential Ankyrin 1 (TRPA1) by the TRP Vanilloid 1-selective Cannabinoid Arachidonoyl-2 Chloroethanolamine. Mol Pharmacol 80:1-7, 2011.
  • Berg K, Rowan M, Sanchez T, Silva M, Pathwardhan A, Hargreaves KM, Clarke W. Regulation of Kappa Opioid Receptor Signaling in Peripheral Sensory Neurons In-vitro and In-vivo. J Pharmacol Expt Therap 338:92-9, 2011.
  • Diogenes A, Ferraz C, Akopian A, Henry M, Hargreaves KM. LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons. J Dent Res 90:759-64, 2011.
  • Hargreaves KM. Orofacial Pain. Pain 152:S25-32, 2011.
  • Lovelace T, Henry M, Hargreaves KM, Diogenes A. Evaluation of the Delivery of Mesenchymal Stem Cells into the Root Canal Space of Necrotic Immature Teeth after Clinical Regenerative Endodontic Procedure. J Endod 37:133-8, 2011.
  • Ferraz C, Henry M, Hargreaves KM, Diogenes A. Lipopolysaccharide from Porphyromonas Gingivalis Sensitizes Capsacin-sensitive Nociceptors. J Endod 37:133-8, 2011.
  • Lautner M, Ruparel S, Patil M, Hargreaves KM. In-vitro Sarcoma Cells Release a Lipophilic Substance that Activates the Pain Transduction System via TRPV1. Ann Surg Oncology 18:866-71, 2011.
  • Ruparel N, Patwardhan A, Akopian A, Hargreaves KM. Homologous and Heterologous Desensitization of Capsaicin and Mustard Oil Responses Utilize Different Cellular Pathways in Nociceptors. Pain 135:271-9, 2008.
  • Patwardhan A, Cerka K, Vela J, Hargreaves KM. Trigeminal Nociceptors Express Prostaglandin Receptor Subtypes EP2 and EP3. J Dent Res 87:262-6, 2008.
  • Akopian A, Ruparel N, Patwardhan A, Hargreaves KM. Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation. J Neurosci 28:1064-75, 2008.
  • Akopian A, Ruparel N, Jeske N, Hargreaves KM. TRPA1 Desensitization in Sensory Neurons is Agonist-dependent and Regulated by TRPV1-directed Internalization.J Physiol 583:175-93, 2007.
  • Diogenes A, Akopian A, Hargreaves KM. NGF Upregulates TRPA1: Implications for Orofacial Pain. J Dent Res 86:550-5, 2007.
  • Gibbs J, Diogenes A, Hargreaves KM. Neuropeptide Y Modulates Effects of Bradykinin and Prostaglandin E2 on Trigeminal Nociceptors via Activation of the Y1 and Y2 Receptors. Br J Pharmacol 150:72-9, 2007.
  • Recent Lectures
  • NYU, August, 2011
Ken M. Hargreaves

Ken M. Hargreaves

Professor and Chair of Endodontics,
Professor of Pharmacology and Physiology
D.D.S., Georgtown University
Ph.D., Uniformed Services University of the Health Sciences

Office: 210-567-3381


View video introduction to Dr. Hargreaves' lab





Research Summary

My primary research interests are in the pharmacology of pain and inflammation. A major focus is on pharmacological regulation of unmyelinated "C" fiber nociceptors, as well as their plasticity in response to inflammation or nerve injury. Investigations are in progress evaluating the effects of cannabinoids, opioids, adrenergics, NPY, sex steroids and other drugs on regulating the activity of these fibers. In addition, we are interested in identifying major classes of inflammatory mediators and associated receptor/signal transduction systems which mediate activation, sensitization and phenotypic plasticity of these primary afferent fibers in response to tissue inflammation. Responses are measured using isolated superfused tissue, primary trigeminal cultures, microdialysis probes implanted in situ, RIA, EIA, real time PCR, Affymetrex analyses, IHC, ISH, confocal microscopy, behavior, etc.

Lab Personnel

Dustin Green - Graduate Student

Michael Eskander - Graduate Student


Hargreaves lab group