PHARMACOLOGY FACULTY
Selected Publications
  • Ruparel N, Patwardhan A, Akopian A, Hargreaves KM. Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors. Pain 135:271-9, 2008.
  • Patwardhan A, Cerka K, Vela J, Hargreaves KM. Trigeminal nociceptors express prostaglandin receptor subtypes EP2 and EP3. J Dent Res 87:262-6, 2008.
  • Akopian A, Ruparel N, Patwardhan A, Hargreaves KM. Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. J Neurosci 28:1064-75, 2008.
  • Akopian A, Ruparel N, Jeske N, Hargreaves KM. TRPA1 desensitization in sensory neurons is agonist-dependent and regulated by TRPV1-directed internalization. J Physiol 583:175-93, 2007.
  • Diogenes A, Akopian A, Hargreaves KM. NGF Upregulates TRPA1: Implications for Orofacial Pain. J Dent Res 86:550-5, 2007.
  • Gibbs J, Diogenes A, Hargreaves KM. Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors. Br J Pharmacol 150:72-9, 2007.
  • Diogenes A, Patwardhan A, Ruparel N, Goffin A, Akopian A, Hargreaves KM. Prolactin Modulates TRPV1 in Female Rat Trigeminal Sensory Neurons. J. Neuroscience 26:8126-36, 2006.
  • Jeske N, Patwardhan A, Gamper N, Price T, Akopian A, Hargreaves KM. Cannabinoid Win 55,212-2 regulates TRPV1 phosphorylation in sensory neurons. J Biol Chem 281(43):32879-32890, 2006.
  • Patwardhan A, Jeske N, Price T, Gamper N, Akopian A, Hargreaves KM. The cannabinoid WIN 55,212 inhibits TRPV1 responses and evokes peripheral antihyperalgesia/antinociception via activation of the calcineurin pathway. Proc Natl Acad Sci USA 103:11393-8, 2006.
  • Patwardhan A, Diogenes A, Berg K, Fehrenbacher J, Clarke W, Akopian A, Hargreaves KM. PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the Delta opioid receptor. Pain 125:114-24, 2006.
  • Gibbs J, Flores C, and Hargreaves KM. Attenuation of capsaicin-evoked mechanical allodynia by peripheral neuropeptide Y Y1 receptors. Pain 124:167-74, 2006.
  • Wadachi R and Hargreaves KM. Trigeminal Nociceptors Express TLR-4 and CD14. A Mechanism for Pain due to Infection. J Dent Res 85:49-52, 2006.
Ken M. Hargreaves
 

Ken M. Hargreaves

Professor and Chair of Endodontics,
Professor of Pharmacology and Physiology
D.D.S., Georgtown University
Ph.D., Uniformed Services University of the Health Sciences

Office: 210-567-3381
Email: Hargreaves@uthscsa.edu

 

View video introduction to Dr. Hargreaves' lab

 

Keywords

KEYWORDS

 

Research Summary

My primary research interests are in the pharmacology of pain and inflammation. A major focus is on pharmacological regulation of unmyelinated "C" fiber nociceptors, as well as their plasticity in response to inflammation or nerve injury. Investigations are in progress evaluating the effects of cannabinoids, opioids, adrenergics, NPY, sex steroids and other drugs on regulating the activity of these fibers. In addition, we are interested in identifying major classes of inflammatory mediators and associated receptor/signal transduction systems which mediate activation, sensitization and phenotypic plasticity of these primary afferent fibers in response to tissue inflammation. Responses are measured using isolated superfused tissue, primary trigeminal cultures, microdialysis probes implanted in situ, RIA, EIA, real time PCR, Affymetrex analyses, IHC, ISH, confocal microscopy, behavior, etc.

 

Hargreaves lab group