PHARMACOLOGY FACULTY
Selected Publications
  • Johnson RA, Johnson FK. Heme oxygenase-derived endogeneous carbon monoxide impairs flow-induced dilation in resistance vessels. (Epub ahead of pring) Shock, Vol. 29, No. 4, pp. 526-530, 2008.
  • Leszl-Ishiguro M, Horvath B, Johnson RA, Johnson FK, Lenzser G, Herman P, Horvath EM, Benyo Z. Influence of the heme-oxygenase pathway on cerebrocortical blood flow. Neuro Report. 2007; 18:1193-1197.
  • Joshi MS, Ferguson TB, Jr., Johnson FK, Johnson RA, Parthasarathy S, Lancaster JR, Jr. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. Proceedings of the National Academy of Sciences, June 2007; 104(24): 9982-9987.
  • Durante W, Johnson FK, Johnson RA. Role of carbon monoxide in cardiovascular function. J Cell Mol Med. Vol 10, No. 3, 2006.
  • Johnson FK, Johnson RA, Durante W, Jackson KE, Stevenson BK, Peyton KJ. Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction in obese Zucker rats. Am J Physiol Regul Integr CompPhysiol. 2006 Mar; 290(3):R601-8. Epub 2005 Nov. 10.
  • Teran FJ, Johnson RA, Stevenson BK, Peyton KJ, Jackson KE, Appleton SD, Durante W, Johnson FK. Heme oxygenase-derived carbon monoxide promotes arteriolar endothelial dysfunction and contributes to salt-induced hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2005 Mar;288(3):R615-22. Epub 2004 Nov. 4.
  • Johnson RA, Teran FJ, Durante W, Peyton KJ, Johnson FK. Enhanced heme oxygenase-mediated coronary vasodilation in Dahl salt-sensitive hypertension. Am J Hypertens. 2004 Jan;17(1):25-30.
  • Johnson FK, Durante W, Peyton KJ, Johnson RA. Heme oxygenase-mediated endothelial dysfunction in DOCA-salt, but not in spontaneously hypertensive, rat arterioles. Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1681-7. Epub 2003 Dec 23.
  • Johnson FK, Johnson RA. Carbon monoxide promotes endothelium-dependent constriction of isolated gracilis muscle arterioles. Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R536-41. Epub 2003 Apr. 3.
Fruzsina K. Johnson
 

Fruzsina K. Johnson

Assistant Professor of Medicine
M.D., Semmelweis University (Hungary)

Office: 210-567-0583
Email: johnsonf@uthscsa.edu

 

Keywords

KEYWORDS

 

Research Summary

Dr. Johnson's research interests include cardiovascular function, microcirculation and vascular pathophysiology, mechanisms of hypertension, and biological roles for porphyrin and gaseous messengers. Her early work demonstrated the importance of endogenously-formed carbon monoxide as a messenger within the vasculature. In subsequent studies, Dr. Johnson has provided compelling evidence that endogenously-formed carbon monoxide not only promotes relaxation of vascular smooth muscle, but can promote vasoconstriction by interfering with the vasodilatory actions of the nitric oxide system. Her research has profound implications as it suggests that endogenously-formed carbon monoxide may contribute to endothelial dysfunction and promote vasospasticity in certain hypertensive models and pathological conditions.