Selected Publications
  • Kikani, CK., Verona, EV., Ryu, J., Shen, Y., Ye, QQ., Zheng, L., Qian, Z., Du, J., Ji, Q., Ogawa, W., Sun, LZ., Dong, LQ. and Liu, F. (2012) Cell proliferative and anti-apoptotic signaling stimulated by nuclear localized PDK1 results in oncogenesis. Science Signaling 5(249), ra80.
  • Liu, M., Xiang, R., Wilk, S.A., Zhang, N., Azarnoush, K., Sloane, L.B., Zhou, L., Chen, H., Xiang, G., Walter, C., Austad, S.N., Musi, N., DeFronzo, R.A., Asmis, R., Scherer, P.E., Dong, L.Q. and Liu, F. (2012) Fat-specific DsbA-L overexpression promotes adiponectin multimerization and prevents mice from diet-induced obesity and insulin resistance. Diabetes 61(11), 2776-86.
  • Zhang, J.J., Zhang, N., Liu, M., Li, X., Zhou, L., Liu, J., Musi, N., DeFronzo, R.A., Cunningham, J.M., Zhou, Z., Lu, X.Y. and Liu, F. (2012) Disruption of Grb10 in the Pancreas Enhances β-cell Proliferation and Protects Mice from Streptozotocin-induced β-cell Apoptosis. Diabetes 61(12), 3189-98.
  • Liu, M., Wilk, SA., Wang, A., Zhou, L., Wang, RH., Ogawa, W., Deng, C., Dong, LQ. and Liu, F. (2010) Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem. 285, 36387-3694.
  • Zhou, L., Liu, M., Zhang, J., Chen, H., Dong, LQ. and Liu, F. (2010) DsbA-L alleviates endoplasmic reticulum stress-induced adiponectin down-regulation. Diabetes 59, 2809-2816.
  • Wang, C., Liu, M., Riojas, RJ., Xin, X., Gao, Z., Zeng, R., Wu, J., Dong, LQ. and Liu, F. (2009) PKCtheta-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. J Biol Chem 284(4), 2038-44.
  • Liu, M., Zhou, LJ., Xu, A., Lam, KSL., Wetzel, MD., Xiang, X., Zhang, JJ., Xin, X., Dong, LQ. and Liu, F. (2008) A disulfide-bond-A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci USA 105, 18302-18307.
Feng Liu

Feng Liu

Professor of Pharmacology
Ph.D., Iowa State University

Office: 210-567-3097


View video introduction to Dr. Liu's lab



Obesity, diabetes, insulin and adipokine signal transduction and regulation


Research Summary

The major focus of our research effort concerns the mechanisms of obesity-induced metabolic diseases such as type 2 diabetes, which is a serious disease that affects 8.3% of the population in the United States. Currently we are using molecular biology, biochemical, and cell biology approaches as well as tissue-specific transgenic and knockout mouse models to identify and characterize key molecules involved in the regulation of glucose metabolism and energy homeostasis. Particularly we are interested in how obesity leads to adipocyte dysregulation and how adipose tissue dysfunction affects whole body energy homeostasis. It is our hope that better understanding of the mechanisms underlying the crosstalk between adipose tissues and other tissues will generate important information for the development of new therapeutic drugs for the treatment of obesity-associated disorders such as Type 2 diabetes, cancer, and aging.

• Lab Personnel •

Dr. Juli Bai - Postdoctoral Fellow

Christopher Cervantes - Research Assistant

Derong Hu - Senior Research Associate

Xin Su, M.D. - Visiting Scientist