PHARMACOLOGY FACULTY
Selected Publications
  • D.J. Lodge, M.M. Behrens & A.A. Grace. (2009) A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia. Journal of Neuroscience 29:5419-08.
  • D.J. Lodge & A.A. Grace. (2008) Amphetamine activation of hippocampal drive of mesolimbic dopamine neurons: A mechanism of behavioral sensitization. Journal of Neuroscience 28:7876-82.
  • D.J. Lodge & A.A. Grace. (2007) Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. Journal of Neuroscience 27: 11424 -30.
  • A.A.Grace, S.B. Floresco, Y. Goto & D.J. Lodge (2007) Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. TRENDS in Neurosciences 30(5):220-7
  • D.J. Lodge & A.A. Grace. (2006) The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons. Proceedings of the National Academy of Sciences 103: 5167-72.
  • D.J. Lodge & A.A. Grace. (2006) The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation. Neuropsychopharmacology 31:1356-61
Daniel Lodge
 

Daniel Lodge

Assistant Professor of Pharmacology

Office: 210-567-4188
Email: lodged@uthscsa.edu

 

View video introduction to Dr. Lodge's lab

 

Keywords

Dopamine, Hippocampus, Schizophrenia, Drug Abuse, Electrophysiology, Neuroscience.

 

Research Summary

The mesolimbic dopamine system regulates the cognitive, motivational and behavioral processes critical to normal functioning. Dysfunction in this system has been linked to a number of psychiatric disorders including schizophrenia and drug abuse. Our research centers around how the mesolimbic dopamine system is regulated by afferent structures, such as the ventral hippocampus. We combine in vivo electrophysiology with activation and/or inactivation of afferent structures to examine how these pathways interact to control dopamine neuron output. To complement this systems-oriented approach, behavioral and neurochemical methods are employed to provide an important correlate for changes observed at the cellular level. Using such an approach, we hope to provide a better understanding into how disturbances in the control of dopamine neuron activity may contribute to psychiatric disorders.


Lab Personnel

Amiksha Shah - Research Assistant

Stephanie Perez - Graduate Student