Selected Publications
  • Lam YWF. Drug Therapy Individualization in Patients with Hepatic Disease or Genetic Alterations in Drug Metabolizing Activity. Pharmacotherapy: A Pathophysiologic Approach 8th edition 2011; 705-716.
  • Cavallari L, Lam YWF. Pharmacogenetics. Pharmacotherapy: A Pathophysiologic Approach 8th edition 2011; 17 and available online.
Y.W. Francis Lam

Y.W. Francis Lam

Professor of Pharmacology

Associate Professor of Medicine
Clinical Associate Professor & James O. Burke Endowed Centennial Fellow in Pharmacy,
Univ. of Texas at Austin
Pharm.D., University of Minnesota

Office: 210-567-8355



drug metabolism, clinical pharmacology, pharmacokinetics, pharmacogenetics


Research Summary

Variability in pharmacologic response to a drug can be partially related to interindividual differences in pharmacokinetics, which can be modulated by an individual's metabolic capacity and concomitant therapy. Development and availability of different in vitro systems over the years have allowed for identification of major cytochrome P-450 isoenzymes and assessment of enzyme inhibition potentials. My primary research interest is on the pharmacodynamic and pharmacokinetic consequences of cytochrome P-450 isoenzymes-mediated drug metabolism. In vivo probes of different isoenzymes are used to investigate the intrinsic and extrinsic variants affecting metabolic capacity, and to investigate the therapeutic utility of metabolic profiling. These probes also allow an opportunity to further address possible genetic and environmental determinants of drug responsiveness among different ethnic groups.


• Appointments, Boards, Committees and Memberships •

Editorial Board Member - Current Pharmacogenomics and Personalized Medicine