Y.W. Francis Lam
Selected Publications
  • Cavallari, L. and Lam, YWF. (2014) Pharmacogenetics. In: Pharmacotherapy: A Pathophysiologic Approach DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM (ed). 9th edition. McGraw-Hill, New York, New York. 2014, complete chapter available online, p 75-94, at with learning objectives and other resources.
  • Lam, YWF. and Cavallari, L. (2013) Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications. In: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation. Lam YWF, Cavallari L (ed). Elsevier, Inc. 2013,1-44.
  • Lam, YWF. (2011) Drug Therapy Individualization in Patients with Hepatic Disease or Genetic Alterations in Drug Metabolizing Activity. Pharmacotherapy: A Pathophysiologic Approach 8th edition 2011; 705-716.
  • Cavallari, L. and Lam, YWF. (2011) Pharmacogenetics. Pharmacotherapy: A Pathophysiologic Approach 8th edition 2011; 17 and available online.

Y.W. Francis Lam

Professor of Pharmacology

Associate Professor of Medicine
Clinical Associate Professor & James O. Burke Endowed Centennial Fellow in Pharmacy,
Univ. of Texas at Austin
Pharm.D., University of Minnesota

Office: 210-567-8355



drug metabolism, clinical pharmacology, pharmacokinetics, pharmacogenetics


Research Summary

Significant variability in efficacy and toxicity of medications among patients is largely attributed to innate differences in their capacity to eliminate and react to medications. Dr. Lam has studied how ethicity and genetic differences affect disposition and response to psychotherapeutic drugs. This has translated to improved understanding of the biological basis for why patients require different doses to elicit appropriate responses, particularly Asians. Dr. Lam’s earlier findings suggested a genetic basis for variation in drug metabolism and response in Mexican Americans in San Antonio. His current focus is whether variation in genes that encode enzymes, transporters, and targets in Hispanics can be utilized for personalized cancer therapy, and is working with CTRC tinvestigators to integrate pharmacogenomics into anticancer drug development.

• Accomplishments, Awards and Honors •

2014 Dental Faculty Assembly Teaching Excellence Award - UTHSCSA - May 2014


• Appointments, Boards, Committees and Memberships •

Editorial Board Member - Current Pharmacogenomics and Personalized Medicine