PHARMACOLOGY

Additional Publications

 

Peng, J., Risinger, AL., Li, J. and Mooberry, SL. (2014) Synthetic Reactions with Rare Taccalonolides Reveal the Value of C-22,23 Epoxidation for Microtubule Stabilizing Potency. J Med Chem 57:6141-6149



Risinger, AL., Rohena, CC., Bennett, MJ., Li, J., Peng, J., Schriemer, DC. and Mooberry, SL. (2013) Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity. Cancer Res 73:6780-6792



Rohena, CC., Peng, J., Johnson, TA., Crews, P. and Mooberry, SL. (2013) Chemically Diverse Microtubule Stabilizing Agents Initiate Distinct Mitotic Defects and Dysregulated Expression of Key Mitotic Kinases. Biochem Pharmacol. 85:1104-14



Risinger, AL., Peng, J., Rohena, CC., Aguilar, HR., Frantz, DE. and Mooberry, SL. (2013) The bat flower: A source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions. J Nat Prod. Oct;76(10):1923-1929



Da, C., Telang, N., Hall, K., Kluball, E., Barelle, P., Finzel, K., Jia, X., Gupton, JT., Mooberry, SL. and Kellogg, GE. (2013) Developing novel C-4 amaogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site. Med Chem Comm 4(2):417-421



Gangjee, A., Zaware, N., Devambatla, RK., Raghavan, S., Westbrook, CD., Dybdal-Hargreaves, NF., Hamel, E. and Mooberry, SL. (2013) Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells. Bioorg Med Chem. 21:891-902.



Peng, J., Hartley, RM., Fest, GA. and Mooberry, SL. (2012) Amyrisins A-C,O -prenylated flavonoids from Amyris madresis. J. Nat. Prod., 75: 494-496.



Da, C., Telang, N., Barelli, P., Jia, X., Gupton, JT., Mooberry, SL. and Kellog, GE. (2012) Pyrrole-based antitubulin agents: two distinct binding modalities are predicted for C-2 analogues in the colchicine site ACS Med Chem Lett Jan 12;3:53-57



Brien, KA., Bandi, RK., Behera, AK., Mishra, BK., Majumdar, P., Satam, V., Savagian, M., Tzou, S., Lee, M., Zeller, M., Robles, AJ., Mooberry, SL., Pati, H. and Lee, M. (2012) Design, synthesis and cytotoxicity of novel chalcone analogs derived from 1-cyclohexylpyrrolidin-2-one and 2,3-dihydrobenzo[f]chromen-1-one. Arch Pharm(Weinheim) May;345:341-348



Hartley, RM., Peng, J., Fest, GA., Dakshanamurthy, S., Frantz, DE., Brown, ML., and Mooberry, SL. (2012) Polygamain, a New Microtubule Depolymerizing Agent that Occupies a Unique Pharmacophore in the Colchicine Site. Mol Pharmacol., 81:431-439.



Da, C., Telang, N., Barelli, P., Jia, X., Gupton, JT., Mooberry, SL. and Kellog, GE. (2012) Pyrrole-Based Antitubulin Agents: Two Distinct Binding Modalities Are Predicted for C-2 Analogues in the Colchicine Site. ACS Med. Chem. Lett., 3:53–57.



Li, J., Risinger, AL., Peng, J., Chen, Z., Hu, L. and Mooberry, SL. (2011) Potent Taccalonolides, AF and AJ, Inform Significant Structure Activity Relationships and Tubulin as the Binding Site of These Microtubule Stabilizers. J Am Chem Soc., 133: 19064-19067.



Peng, J., Risinger, AL., Fest, GA., Jackson, EM., Helms, G., Polin, LA. and Mooberry, SL. (2011) Identification and biological activities of new taccalonolides microtubule stabilizers. J Med Chem., 54: 6117-24.



Risinger, AL. and Mooberry, SL. (2011) Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel. Cell Cycle, 10, 2162-2171.