PHARMACOLOGY

Additional Publications

 

Majumder, S., Caccamo, A., Benavides AD., Javors, MA., Kraig, E., Strong, R., Richardson A., and Oddo, S. (2012) Life-long rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1ß signaling Aging. Cell 11:326-335



Wey, M.C-Y., Fernandez, E., Martinez, PA. Sullivan, Goldstein, DS. and Strong, R. (2012) Nigrostriatal Neurodegeneration and Impaired Motor Function in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson’s Disease. PLoS ONE 7(2):e31522



Wilkinson, JE., Burmeister, L., Brooks, SV., Carames, B.,Friedline, S. Harrison, DE., Lotz, M., Nadon, N., Strong, R. and Wood, LK. (2012) Rapamycin Slows Aging in Mice. Aging Cell 11:675-682



Nelson, JF., Strong, R., Bokov, A., Diaz, V. and Ward, W. (2012) Probing the relationship between insulin sensitivity and longevity using genetically modified mice. J. Gerontol. A Biol. Sci. Med. Sci Jan;67:1332-1338



Roth, MK., Bingham, B., Shah, A., Joshi, A., Frazer, A., Strong, JR. and Morilak, DA. (2012) Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity. Neuropharmacology 63(6):1118-1126



Halloran, J., Hussong, S., Burbank, R., Podlutskaya, N., Fischer, K., Sloane, L., Austad, SN., Strong, R., Richardson, A., Hart, M. and Galvan, V. (2012) Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience Oct 25;223:102-13



Ramos, F., Chen, SC., Garelick, MG., Dai, DF., Liao, CY., Schreiber, KH., MacKay, VL., An, EH., Strong, R., Ladiges, WC., Rabinovitch, PS., Kaeberlein M. and Kennedy, BK. (2012) Rapamycin reverses elevated mTORC1 signaling in lamin A/C deficient mice, to rescue cardiac and skeletal muscle function and extend survival. Science Transl Med. Jul;4(144):144-ra103



Miller, RA., Harrison, DE., Astle, CM., Baur, JA., Rodriguez Boyd, A., de Cabo, R., Fernandez, E., Flurkey, K., Javors, MA., Nelson, JF., Orihuela, CJ., Pletcher, S., Sharp, ZD., Sinclair, D., Starnes, JW., Wilkinson, JE., Nadon, NL. and Strong, JR. (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 66A(2):191-201



Green, MK., Rani, CSS., Joshi, A., Soto-Pina, AE., Martinez, PA., Frazer, A., Strong, JR. and Morilak, DA. (2011) Prenatal stress induces long term stress vulnerability, compromising stress response systems in the brain and impairing extinction of conditioned fear after adult stress. Neuroscience 192:438-451



Majumder, S., Richardson, A., Strong, R. and Oddo S.(2011) Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS One Jun;6(e25416)



Spilman, P., Podlutskaya, N., Hart, MJ., Debnath, J., Gorostiza, O., Bredesen, DE., Richardson, A., Strong, JR. and Galvan, V. (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS ONE Apr;5(4):e9979



Caccamo, A., Majumder, S., Richardson, A., Strong, JR. and Oddo S (2010) Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem 285:13107-13120



Frahm, KF., Lumia, AR., Fernandez, E., Strong, JR., Roberts, JL. and McGinnis, MY. (2010) Effects of Anabolic Androgenic Steroids and Social Subjugation on Behavior and Neurochemistry in Male Rats Pharmacol Biochem Behav Jan;97:416-422



Sharp, ZD. and Strong, R. (2010) The role of mTOR signaling in controlling mammalian lifespan: what a fungicide teaches us about longevity. J Gerontol A Biol Sci Med Sci. Jun;65(6):580-589



Khodr, CE., Clark, S., Bokov, AF., Richardson, A., Strong, R., Hurley, DL. and Phelps, CJ. (2010) Early postnatal administration of growth hormone increases tuberoinfundibular dopaminergic neuron numbers in Ames dwarf mice. Endocrinology Jul;151(7):3277-3285