Louisiana State University Medical Center
New Orleans, Louisiana
benzodiazepine, neuroactive steroid, dependence, tolerance
Studies conducted in this laboratory examine the acute and chronic behavioral effects of benzodiazepines and other positive GABAA modulators, particularly neuroactive steroids. Benzodiazepine tolerance and dependence differentially alters the effects of positive GABAA modulators, depending on their site of action.
Our primary research goal is to investigate changes in GABAA receptor function with benzodiazepine tolerance and dependence, discover the nature of differences between the effects of neuroactive steroids and those of benzodiazepines, and determine whether these differences can be exploited for clinical benefit.
Appointments, Boards, Committees and Memberships
06/98-Present - College on Problems of Drug Dependence
11/93-Present - Society for Stimulus Properties of Drugs