Flavia Carreno
Selected Publications

Flavia Carreño

Ph.D., Cellular and Tissue Biology
University of São Paulo
São Paulo, SP, Brazil

Lab Association:Alan Frazer, Ph.D.


Research Interests

• Vagal nerve stimulation • antidepressants
• treatment resistant depression             • neurotrophins
• TrkB receptor

Research Activities

My current research focuses on alternative therapies for treatment resistant depression. Based on our recently published data showing that the sustained antidepressant-like response to ketamine is dependent on the activation of the ventral hippocampus, we propose a more translationally relevant approach by selectively targeting the hippocampus pharmacologically. In particular, we are exploiting the discrete localization of the alpha5-subunit of the GABAA receptor to modulate preferentially hippocampal activity. We have also published that such an approach produces an antidepressant-like response without the psychotomimetic effects and abuse related properties associated with the use of ketamine. Currently we are studying the mechanisms by which pharmacological augmentation of hippocampal activity produces sustained antidepressant-like effects.


• Accomplishments, Awards and Honors •

Chair's Award for Excellence - Research - Dec 2014

William Thomas Booth Memorial Travel Award - UTHSCSA - Sept 2014

• Appointments, Boards, Committees and Memberships •

Reviewer for Journals - Biological Psychiatry - 2018-Present

Poster Judge - APSA Meeting (2018), BBC Meeting (2016), Pharmacology Graduate Student Symposium (2015), Passport Retreat (2015)

Chemical Safety Committee Member - UTHSA - 2017-Present

START-UP Recruitment Team - St. Mary's University - 2017

Member of Center for Biomedical Neuroscience (CBN) - 2016-Present

Reviewer for Journals - Brain Stimulation - 2015-Present

Reviewer for Journals - International Journal of Neural Systems - 2015-Present

Reviewer for Journals - Neuropharmacology - 2015-Present

Grant Reviewer (ad hoc) - William & Ella Owens Medical Research Foundation - 2015

Brain Bowl Judge - UTHSCSA - 2015

Reviewer for Journals - PLOS ONE - 2014-Present

Reviewer for Journals - Neural Regeneration Research - 2014-Present

Natalia High School Science Night - Registration Booth Organizer - San Antonio, TX - 2014

Reviewer for Journals - Journal of Chemical Neuroanatomy - 2012-Present

Organizing committee for R25 students Journal Club - Department of Pharmacology, UTHSCSA, TX - Dec 2011-Present

Member of American Physiological Society (APS) - 2009-Present

Member of the Cardiovascular Research Institute (CRI) - 2009-Present

Member of the Society for Neuroscience (SfN) - 2005-Present

• Certifications and Training •

Genome Sequencing Facility, UTHSCSA - Workshop attendee: RNA-seq (4 hours) - 2015

Office of Postdoctoral Affairs, UTHSCSA - Course attendee: Entering Mentorship (8 hours) - 2014

• Grants, Funding and Research Support •

Center for Biomedical Neuroscience (CBN) pilot project grant - (Role: PI); 01/01/2015-12/31/2017: $50,000.00. - Title: Brain circuits underlying the antidepressant-like and abuse-related effects of ketamine

• Lectures and Presentations •

Ketamine and Beyond: Novel Treatments for Major Depressive Disorder - Pharmaceutical Sciences School seminar, UFRGS - Porto Alegre RS, Brazil - 2016

BDNF Receptor Signaling is Differentially Altered by Novel Antidepressants - ASPET Symposium speaker at Experimental Biology 2016, San Diego, CA

Brain circuits underlying the antidepressant response to ketamine: preclinical studies - Department of Pharmacology Seminar - UTHSCSA - 2015

Current Approaches and Technologies to Study Antidepressant Drugs in the Laboratory - UTHSCSA Voelcker Biosciences Teacher Academy 5th Annual Spring Conference - San Antonio, TX - 2014

How we study antidepressant drugs in the laboratory - UTHSCSA Health Professions Fair & Science Expo - 2013

Life as a scientist - Special presentation to R25 students/Round table - UTHSCSA - 2013