PHAR 5091.006

Title: Serotonin: From Soup (Transmission) to Nuts (Behavior)

Faculty: Drs. Alan Frazer & Julie Hensler

Content of course: This one credit elective course consists of sixteen sessions covering the history of serotonin, its early pharmacology, and its behavioral functions.

Session 1: Discovery of Serotonin

1. Rapport M.M.; Green A.A.; Page I.H.: Crystalline Serotonin. Science 108:329-330, 1948.
2. Rapport M.M.; Green A.A.; Page I.H.: Serum Vasoconstrictor (Serotonin) IV. Isolation and Characterization. The Journal of Biological Chemistry 176:1243-1251, 1948.

Session 2: Serotonin in Brain

1. Twarog B.M.; Page I.H.: Serotonin Content Of Some Mammalian Tissues And Urine And A Method For Its Determination. American Journal of Physiology 175:157-161, 1953.

Session 3,4: Neuroanatomy

1. Dahlstrom A and Fuxe K: Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in cell bodies of brain neurons. Acta Physiologica Scandinavica [suppl 232] 62: 1-55, 1964.
2. Geyer MA, Puerto A, Dawsey WJ, Knapp S, Bullard WP and Mandell AJ: Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways. Brain Research 106: 214-256, 1976.
3. Kosofsky BE and Molliver ME. The seroninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse 1: 153-168, 1987.

Session 5, 6,7, 8: Serotonin Receptors -pharmacology, signal transduction and classification

1. Gaddum J.H.: Drugs Antagonistic To 5-Hydroxytryptamine. In Gaddum (Ed.) Ciba Foundation Symposium on Hypertension: Humoral and Neurogenic Factors pp. 75-77, Little Brown, Boston, 1954.
2. Gaddum J.H.; Picarelli Z.P.: Two Kinds Of Tryptamine Receptor. The British Journal of Pharmacology 12:323-328, 1957.
3. Peroutkia S.J.; Snyder S.H.: Multiple Serotonin Receptors: Differential Binding Of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide And [3H]Spiroperidol. Molecular Pharmacology 16:687-699, 1979.
4. Pedigo N.W.; Yamamura H.I.; Nelson D.L.: Discrimination Of [3H]5-Hydroxytryptamine Binding Sites By The Neuroleptic Spiperone In Rat Brain. Journal of Neurochemistry 36:220-226, 1981.
5. Hartig PR: Molecular biology of 5-HT receptors. Trends in Pharmacological Science 10: 64-69, 1989.
6. Hoyer D., et al. International Union of Pharmacology classification of receptors for 5-hydroxytramine (serotonin). Pharmacological Reviews 46: 157-203, 1994.

Session 9, 10: Volume Transmission

1. Richards JG, Saura J, Ulrich J and Da Prada M: Molecular neuroanatomy of monoamine oxidases in human brainstem. Psychopharmacology 106:S21-S23, 1992.
2. Tao-Cheng J-H and Zhou FC: Differential polarization of serotonin transporters in axons versus soma-dendrites: an immunogold electron microscopy study. Neuroscience 94: 821-830, 1999.
3. Riad M, Garcia S., Watkins KC, Jodoin N, Doucet E, Langlois X, El Mestikawy S, Hamon M and Descarries L.: Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain. The Journal of Comparative Neurology 417: 181-194, 2000.

Session 11: Behavioral Roles for 5-HT in Brain

1. Brodie B.B.; Shore P.A.: A Concept For A Role of Serotonin And Norepinephrine As Chemical Mediators In The Brain. Annals of the New York Academy of Sciences 66:631-642.
2. Brodie B.B.; Comer M.S.; Costa E.; Dlabac A.: The Role Of Brain Serotonin In The Mechanism Of The Central Action Of Reserpine. The Journal of Pharmacology and Experimental Therapeutics 152:340-349, 1966.

Session 12: Serotonin Depletion

1. Koe B.K.; Weissman A.: p-Chlorophenylalanine: A Specific Depletor Of Brain Serotonin. The Journal of Pharmacology and Experimental Therapeutics 154:499-516, 1966.
2. Harvey J.A.; Schlosberg A.J.; Yunger L.M.: Behavioral Correlates Of Serotonin Depletion. Federation Proceedings 34:1796-1801, 1975.

Session 13: Serotonin and Behavioral Suppression

1. Soubrié P.: Reconciling The Role Of Central Serotonin Neurons In Human And Animal Behavior. The Behavioral and Brain Sciences 9:319-363, 1986.

Session 14: Serotonin and Neural Information Processing

1. Spoont M.R.: Modulatory Role Of Serotonin In Neural Information Processing: Implications For Human Psychopathology. Psychological Bulletin 112:330-349, 1992.

Session 15: Serotonin and Delay

1. Bizot J.C.; Bihan C.L.; Puech A.J.; Hamon M.; Thiébot M.H.: Serotonin And Tolerance To Delay Of Reward In Rats. Psychopharmacology 146:400-412, 1999.
2. Dalley J.W.; Theobald D.E.; Eagle, D.M.; Passetti F.; Robbins T.W.: Deficits In Impulse Control Associated With Tonically-Elevated Serotonergic Function In Rat Prefrontal Cortex. Neuropsychopharmacology 26:716-728, 2002.

Session 16: Drugs and the Central Serotonin System

1. Spinks D and Spinks G: Serotonin reuptake inhibition: an update on current research strategies. Current Medicinal Chemistry 9: 799-810.
2. Montoy AG, Sorrentino R, Lukas SE and Price BH: Long-term neuropsychiatric consequences of "ecstasy" (MDMA): a review. Harvard Review Psychiatry 10: 212-220, 2002.

Grading Mechanism: Original research articles will be read and presented by the student. There will be a written paper (8-10 stages) prepared by the student at the end of the elective that covers the material read. The final grade will be on a lettered scale and based equally on the oral presentations and the written paper.

Pre-requisites: Principles of Pharmacology, Fundamentals of Neuroscience

Credit Hours: 1 credit hour

Restrictions: None