25th Annual Arthur H. Briggs Lectureship
Thursday, October 11th, 2018 @ 4:00PM
Medical Bldg - Lecture Hall Room 309L


Dr. Arthur BriggsDr. Arthur H. Briggs (pictured left) served as Chair of the Department of Pharmacology at UTHSCSA from 1968 - 1993, during which time he studied the actions of drugs on the cardiovascular system, hypertension, and drugs of abuse. His laboratory published the first papers on the central role of calcium in vascular smooth muscle contraction and the interrelationships between sodium and potassium ions and drugs. These studies led to important advances in the understanding of calcium in smooth muscle function. Since his retirement in 1993, an annual lectureship has been held in his honor.

This year’s guest lecturer, Jonathan A. Javitch, MD, PhD (below), is currently the Lieber Professor of Experimental Therapeutics in Psychiatry and Professor of Pharmacology in the Center for Molecular Recognition at the College of Physicians and Surgeons, Columbia University, New York.

His research covers two main topics, one of which is aimed at understanding the structural bases of agonist and antagonist binding and specificity of dopamine D2-like receptors and related biogenic amine receptors, how agonist binding is transduced into G protein activation and the structural basis for G protein-coupled receptor (GPCR) oligomerization and its role in signaling.

A second area of research focuses on determining the structural bases of the transport of substrate by the dopamine transporter and its inhibition by drugs such as cocaine and amphetamine. He is also studying the regulation of the trafficking and function of the dopamine transporter and its role in sensitization. Several lines of evidence support the relevance of sensitization to the pathophysiology of schizophrenia, including the ability of amphetamine and other psychostimulants to induce psychosis in normal subjects and to the increased sensitivity of patients with schizophrenia to the psychotogenic effects of psychostimulants.

Techniques used in the pursuit of such studies include using a number of bacterial homologs of the neurotransmitter transporters as model systems for direct structural studies, including X-ray crystallography, EPR spectroscopy, and single-molecule fluorescence spectroscopy.


Dr. Jonathan A. Javitch
25th Annual Arthur H. Briggs Guest Lecturer Jonathan A. Javitch, M.D., Ph.D.


Dr. Joan Heller Brown, 2017
Dr. Bruce A. Littlefield, 2016
Dr. Peter Senter, 2015
Dr. Husseini K. Manji, 2014
Dr. P. Jeffrey Conn, 2013
Dr. Michel Bouvier, 2012
Dr. James H. Woods, 2011
Dr. Floyd E. Bloom, 2010
Dr. Mark Von Zastrow, 2009
Dr. Tomas Hökfelt, 2008
Dr. Marc Caron, 2007
Dr. Terry Kenakin, 2006
Dr. G. Stanley McKnight, 2005
Dr. Brian Kobilka, 2004
Dr. David J. Triggle, 2003
Professor James Black, 2002
Dr. Raymond J. Dingledine, 2001
Dr. William A. Catterall, 2000
Dr. Henry Bourne, 1999
Dr. Ira Black, 1998
Dr. Lee E. Limbird, 1997
Dr. Ian Creese, 1996
Dr. Michael Moskowitz, 1995
Dr. Perry Molinoff, 1994