13th Annual Center for Biomedical Neurosciences (CBN)
Spring Scientific Retreat
Friday, May 8th, 2015 - 8:00AM-4PM
North Campus GCCRI Commons and Auditorium
The Center for Biomedical Neurosciences (CBN) will hold it's thirteeth annual retreat on Friday, May 8th, 2015. Professor of Pharmacology and CBN Director, Dr. David Morilak (pictured below, right), is again this year's event host and coordinator. Poster presentations will provide an opportunity for CBN members to discuss their research with colleagues. Over forty (40) posters are expected to be presented at this year's event. The event will begin with poster presentations and judging (a lite breakfast will be available), followed by a round of three guest speaker presentations, a second round of poster presentations and judging, a boxed lunch break, the Invited Speaker address and the retreat will conclude with the poster presentation awards.
This year's Invited Speaker will be Roger Nicoll, M.D. (pictured left), a Professor with the University of California San Francisco (UCSF) School of Medicine, in the Department of Cellular Molecular Pharmacology, at San Francisco, California. His lab is interested in elucidating the cellular and molecular mechanisms underlying learning and memory in the mammalian brain. Long-term potentiation (LTP), a phenomenon in which brief repetitive activity causes a long lasting (many weeks) enhancement in the strength of synaptic transmission, is generally accepted to be a key cellular substrate for learning and memory. The lab uses a combination of electrophysiological and molecular techniques to elucidate the molecular basis of LTP. They have found that LTP involves the rapid activity-dependent trafficking of glutamate receptors to the synapse. This trafficking requires the interaction of two families of synaptic proteins. One family is a novel group of proteins that, we discovered which bind to glutamate receptors and act as auxiliary subunits. These proteins are not only essential for the trafficking of the glutamate receptors, but also control the gating of the receptor channel. The other family is comprised of a family of scaffolding proteins that bind to the auxiliary subunits and thereby anchor the receptors at the synapse. Much of the current work in the lab is focused on how activity controls this receptor trafficking and how the increase in synaptic strength during LTP is stabilized and maintained.
As our main model system, we are focused on the rodent hippocampus, specifically the CA3 to CA1 synapse, though we also study from the CA3 and dentate gyrus region of the hippocampus, from the cerebellum, and from heterologous cells.
A sampling of some of the current projects in Dr. Nicoll's lab are: AMPA receptor subunits in receptor trafficking, MAGUK scaffolding proteins in anchoring synaptic AMPA receptors, conditional knock out mice to explore the role of synaptic proteins in glutamate receptor trafficking, TARPs control of AMPA receptor gating and activity dependent trafficking of NMDA receptors. Dr. Nicoll's address is titled: 'Long Term Potentiation: the bare bones'.
Prior to the Invited Speaker, the CBN Retreat hosts three Platform Speakers, who this year will be: Dr. Mark Shapiro, Department of Physiology, presenting: 'Super-resolution STORM microscopy reveals clustering of diverse ion channels in neurons using visible light', Dr. Lance McMahon, Department of Pharmacology, with his presentation: 'Cannabis-like effects of endogenous cannabinoid metabolic inhibitors' and the final speaker will be Dr. Eileen Lafer, Department of Biochemistry, discussing 'The Synaptic Vesicle Cycle'.
Abstracts are being accepted now through Friday, April 10th, 2015. Submit your abstract and category (Student, Research/Technical, Postdoctoral Fellow, Junior Faculty and Undergraduate) to Thelma Aguirre, at email address firstname.lastname@example.org by the April 10th deadline - LOOK FORWARD TO SEEING YOU THERE!!!