14th Annual Center for Biomedical Neurosciences (CBN)
Spring Scientific Retreat
Friday, May 6th, 2016 - 8:30AM-4PM
North Campus GCCRI Commons and Auditorium
The Center for Biomedical Neurosciences (CBN) will hold it's fourteenth annual retreat on Friday, May 6th, 2016. Professor of Pharmacology and CBN Director, Dr. David Morilak (pictured below, right), is again this year's event host and coordinator. Poster presentations will provide an opportunity for CBN members to discuss their research with colleagues. Over forty (40) posters are expected to be presented at this year's event. The event will begin with poster presentations and judging (a lite breakfast will be available), followed by a round of three guest speaker presentations, a second round of poster presentations and judging, a boxed lunch break, the Invited Speaker address and the retreat will conclude with the poster presentation awards.
This year's Invited Speaker will be Bryan L. Roth, M.D., Ph.D. (pictured left), the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, Department of Pharmacology and Division of Medicinal Chemistry & Natural Products, Eshelman School of Pharmacy at the University of North Carolina, School of Medicine. G-protein coupled receptors (GPCRs) represent one of the most evolutionarily diverse superfamilies of the human genome. My lab studies all aspects of GPCR structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. Currently we are focused on members of the serotonin (5-hydroxytryptamine; 5-HT) and opioid receptor families and their accessory proteins.
We invented the chemogenetic technology dubbed: DREADD (Designer Receptors Exclusively Activated by Designer Drug) which is currently used by 100’s of labs around the world.
We are actively engaged in drug discovery efforts via the shared resources of the National Institute of Mental Health's Psychoactive Drug Screening Program. Our goals are to discover and develop novel small molecule probes for in vitro and in vivo validation of molecular targets for therapeutic drug discovery. We have particular strengths with GPCR and ion-channels and have expanded our capabilities to enable screening of the entire GPCR-ome in massively parallel screening campaigns. Dr. Roth's address is titled: 'New insights into psychoactive drug actions'.
Prior to the Invited Speaker, the CBN Retreat hosts three Platform Speakers, who this year will be: Kelly Berg, Ph.D., Department of Pharmacology, presenting: 'The curious case of opioid receptor regulation in painsensing neurons', Milena Girotti, Ph.D., Department of Pharmacology, with her presentation: 'A role for JAK-STAT signaling in cognitive function' and the final speaker will be Jason Pugh, Ph.D., Department of Physiology, discussing 'What are presynaptic GABA receptors doing at an excitatory synapse?'.