Xi 'Stephen' Chen

Xi 'Stephen' Chen


Chengdu, China


Info Pending

Lab Association

Ralph A. Defronzo, M.D.

Hobbies and Interests

Traveling and spending time with family


My research is focused on understanding the regulation mechanisms of the diabetes gene TCF7L2 underlying adipose tissue development and differentiation for type 2 diabetes.

• Books and Publications •

Norton, L., Chen, X., Fourcaudot, M., Acharya, N., DeFronzo, RA. and Heikkinen, S. (2014) The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. Nucleic Acids Research. Nov; PMID: 25414334

Hwang, K., Trama, AM., Kozink, DM., Chen, X., Wiehe, K., Cooper, AJ., Xia, S., Wang, M., Marshall, DJ, Whitesides, J., Alam, M., Tomaras, GD., Allen, SL., Rai, KR., McKeating, J., Catera, R., Yan, X., Chu, CC., Kelsoe, G., Liao, H., Chiorazzi, N. and Haynes, BF. (2014) IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. PLoS One. Mar 10;9(3):e90725; PMID: 24614505

Bonsignori, M., Wiehe, K., Grimm, SK., Lynch, R., Yang, G., Kozink, DM., Perrin, F., Cooper, AJ., Hwang, K., Chen, X., Liu, M., McKee, K., Parks, RJ., Eudailey, J., Wang, M., Clowse, M., Criscione-Schreiber, LG., Moody, MA., Ackerman, ME., Boyd, SD., Gao, F., Kelsoe, G., Verkoczy, L., Tomaras, GD., Liao, H., Kepler, TB., Montefiori, DC., Mascola, JR. and Haynes, BF. (2014) An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. J Clin Invest. Apr 1;124(4):1835-43; PMID: 24614107

Tomarasa, GD., Ferraria, G., Shena, X., Alama, S.M., Liao, H., Pollaraa, J., Bonsignoria, M., Moody, M.A., Fong, Y., Chen, X., Poling, B., Nicholson, C., Zhang, R., Lu, X., Parks, R., Kaewkungwal, J., Nitayaphan, S., Pitisuttithum, P., Rerks-Ngarm, S., Gilbert, P.B., Kim, J.H., Michael, N.L., Montefiori, D.C. and Haynes, B.F. (2013) HIV-1 vaccine-induced envelope gp120 C1-region IgA blocks binding and effector function of gp120 IgG PNAS. May; PMID: 23661056

Liao, HX., Bonsignori, M., Alam, S.M., McLellan, J.S., Tomaras, G.D., Moody, M.A., Kozink, D.M., Hwang, KK., Chen, X., Tsao, CY., Liu, P., Lu, X., Parks, R., Montefiori, D., Ferrari, G., Rao, M., Peachman, K.K., Santra, S., Letvin, N.L., Karasavvas, N., Yang, ZY., Dai, K., Pancera, M., Gorman, J., Nicely, N.I., Rerks-Ngarm, S., Nitayaphan, S., Kaewkungwal, J., Pitisuttithum, P., Tartaglia, J., Sinangi, F., Kim, J.H., Michael, N.L., Kwong, P.D., Mascola, J.R., Nabel, G.J., Pinter, A., Zolla-Pazner, S. and Haynes, B.F. (2013) HIV-1 Vaccine Induces Antibodies Against a V1/V2 Structural Site of Immune Pressure Immunity. Jan; 38(1):176-86. PMID:23313589

Bonsignori, M., Pollara, J., Moody, M.A., Alpert, M., Chen, X., Hwang, KK., Gurley, T.C., Kozink, D.M., Marshall, D.J., Whitesides, J.F., Tsao, CY., Kaewkungwal, J., Nitayaphan, S., Pitisuttithum, P., Rerks-Ngarm, S., Kim, J., Michael, N., Tomaras, G.D., Montefiori, D.C., Lewis, G., DeVico, A., Evans, D., Ferrari, G., Liao, HX. and Haynes, B.F. (2012) ADCC-Mediating HIV-1 Envelope Monoclonal Antibodies From ALVAC-HIV/AIDSVAX-B/E RV144 Vaccinees Preferentially Use Variable Heavy 1 (VH1) Family Immunoglobulin Genes Journal of Virology. Nov; 86(21):11521-32. PMID:22896626

Bar, K.J., Tsao, CY, Iyer, S.S., Decker, J.M., Yang, Y., Bonsignori, M., Chen, X., Hwang, KK, Montefiori, D.C., Liao, HX., Hraber, P., Fischer, W., Li, H., Wang, S., Sterrett, S., Keele, B.F., Ganusov, V.V., Perelson, A.S., Korber, B.T., Georgiev, I., McLellan, J.S., Pavlicek, J.W., Gao, F., Haynes, B.F., Hahn, B.H., Kwong, P.D. and Shaw, G.M. (2012) Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape PLoS Pathogens. May; 8(5):e1002721. PMID:22693447

Moody, M.A., Yates, N.L., Amos, J.D., Drinker, M.S., Eudailey, J.A., Gurley, T.C., Marshall, D.J., Whitesides, J.F., Chen, X., Foulger, A., Yu, JS., Zhang, R., Meyerhoff, R.R., Parks, R., Wang, L., Vandergrift, N.A., Meguid, N., Pollara, J., Kelsoe, G., Alam, S.M., Ferrari, G., Montefiori, D.C., Voss, G., Liao, HX., Tomaras, G.D. and Haynes, B.F. (2012) HIV-1 gp120 Vaccine Induces Affinity Maturation in Both New and Persistent Antibody Clonal Lineages Journal of Virology PMID:22553329

Bonsignori, M., Montefiori, D., Wu, X., Chen, X., Hwang, KK., Tsao, CY., Kozink, D., Parks, R., Tomaras, G., Crump, J., Kapiga, S., Sam, N., Kwong, P., Kepler, T., Liao, HX., Mascola, J., and Haynes, B. (2012) Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-infected Donor: Implications for Vaccine Design Journal of Virology Feb 1; PMID:22301150

Hwang, KK., Chen, X., Kozink, D.M., Gustilo, M., Marshall, D.J., Whitesides, J., Liao, HX., Catera, R., Chu, C.C., Yan, XJ., Luftig, M., Haynes, B.F. and Chiorazzi, N. (2012) Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by co-culture with macrophage feeder cells Blood Feb 16;119(7):e35-44; PMID:22160618

Liao, HX., Chen, X., Munshaw, S., Zhang, R., Marshall, D.J., Vandergrift, N., Whitesides, J.F., Lu, X., Yu, JS., Hwang, KK., Gao, F., Markowitz, M., Goepfert, P., Shaw, G., Alam, M., Margolis, D., Denny, T.N., Boyd, S.D., Marshal, E., Egholm, M., Simen, B., Hanczaruk, B., Fire, A.Z., Voss, G., Kelsoe, G., Tomaras, G., Moody, M.A., Kepler, T.B. and Haynes, B.F. (2011) Antibodies to Transmitted HIV-1 gp41 ENV are Polyreactive and Have Characteristics of Origin From Mutated Memory B Cells J. Exp. Med. Oct. 24;208(11):2237-49; PMID:21987658

Morris, L., Chen, X., Alam, M., Tomaras, G., Zhang, R., Marshall, D., Chen, B., Parks, R., Foulger, A., Jaeger, F., Donathan, M., Bilska, M., Gray, E.S., Karim, S.S.A., Kepler, T.B., Whitesides, J., Montefiori, D., Moody, M.A., Liao, HX. and Haynes, B.F. (2011) Isolation of a Human Anti-HIV gp41 Membrane Proximal Region Neutralizing Antibody by Antigen-Specific Single B Cell Sorting PLoS ONE Sep. 6(9): e23532; PMID:21980336

Moody, M.A., Zhang, R., Walter Jr., E.B., Woods, C.W., Ginsburg, G.S., McClain, M.T., Denny, T.N., Chen, X., Munshaw, S., Marshall, D.J., Whitesides, J.F., Drinker, M.S., Amos, J.D., Gurley, T.C., Eudailey, J.A., Foulger, A., DeRosa, K.R., Parks, R., Meyerhoff, R.R., Yu, JS., Kozink, D.M., Barefoot, B.E., Ramsburg, E.A., Khurana, S., Golding, H., Vandergrift, N.A., Alam, S.M., Tomaras, G.D., Kepler, T.B., Kelsoe, G., Liao, HX. and Haynes, B.F. (2011) H3N2 Influenza Infection Elicits More Cross-reactive and Less Clonally Expanded Anti-hemagglutinin Antibodies than Influenza Vaccination PLoS ONE. 6(10): e25797; PMID:22039424

Bonsignori, M., Hwang, KK., Chen, X., Tsao, CY., Morris, L., Gray, E., Marshall, D.J., Crump, J.A., Kapiga, S.H., Sam, N.E., Sinangil, F., Pancera, M., Yongping, Y., Zhang, B., Zhu, J., Kwong, P.D., O’Dell, S., Mascola, J.R., Wu, L., Nabel, G.J., Phogat, S., Seaman, M.S., Whitesides, J.F., Moody, M.A., Kelsoe, G., Yang, X., Sodroski, J., Shaw, G.M., Montefiori, D., Kepler, T.B., Tomaras, G.D., Alam, S.M., Liao, HX. and Haynes, B.F. (2011) Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Journal of Virology Aug;85(15):7719-29 PMID:21795340

Gray, ES., Moody, MA., Wibmer, CK., Chen, X., Marshall, D., Amos, J., Moore, PL., Foulger, A., Yu, JS., Lambson, B., Karim, SA., Whitesides, J., Tomaras, GD., Haynes, BF., Morris, L., Liao, HX. (2011) Isolation of a monoclonal antibody targeting the alpha-2 helix of gp120 representing the initial autologous neutralizing antibody response in an HIV-1 subtype C infected individual. Journal of Virology Aug; 85(15):7719-29; PMID:21613396