PHARMACOLOGY GRADUATE STUDENTS

Michael Eskander

 
Michael Eskander

Hometown

Coppell, Texas


Education

BS, Psychology (Minor in Biology)

The University of Texas - Austin, Texas


Lab Association

Kenneth Hargreaves, DDS, Ph.D.


Hobbies and Interests

Sports, Dallas Mavericks, Dallas Cowboys, Movies & TV, Music, Halo and Dogs


Research

Chronic pain disorders represent a major cost to society (>$100 billion) and the impact in terms of loss of quality of life cannot even be estimated. The mechanisms mediating the transition from a normal healthy state to a chronic pain disorder are poorly understood. Michael's research is focusing on cellular mechanisms leading to persistent changes in nociceptor phenotype, resulting in persistent activation of peripheral nociceptive neurons and the development of a chronic pain state. Understanding these mechanisms is important since they may lead to novel therapies for pain management.



• Accomplishments, Awards and Honors •

Travel Award - International Association for the Study of Pain (IASP) 15th World Congress on Pain - Buenos Aires, Argentina - Oct 2014


Received Best Oral Presentation award - UTHSCSA GSBS 6th Annual Terry Mikiten Graduate Student Research Forum - June 2014


National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke Research Fellowship Award - 1F31NS083358-01A1 - August 2013-2015


Received Outstanding Poster Award - 2012 Behavior, Biology and Chemistry Conference - March 2012


Dean's Excellence Award - UTHSCSA - 2010



• Appointments, Boards, Committees and Memberships •

International Association for the Study of Pain


Society for Neuroscience (SfN)



• Books and Publications •

Eskander, MA., Ruparel, S., Green, DP., Chen, PB., Por, ED., Jeske, NA., Gao, X. and Hargreaves, KM. (2015) Persistent nociception triggered by nerve growth factor is mediated by TRPV1 and oxidative mechanisms J Neurosci.


Rowan, MP., Bierbower, SM., Eskander, MA., Por, ED., Gomez, R., Veldhuis, N., Bunnett, NW. and Jeske, NA. (2014) Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross talk PLoS One Apr 2;9(4):e93688


Ruparel, S., Hargreaves, KM., Eskander, M., Rowan, S., de Almeida, JFA., Roman, L. and Henry, MA. (2013) The oxidized linoleic acid metabolite-cytochrome P450 system is active in biopsies from patients with inflammatory dental pain Pain 154(11):2363-2371



• Lectures, Posters and Presentations •

UTHSCSA Dental Science Symposium - San Antonio, TX - 2015
Eskander, M., Sun, X. and Hargreaves, K. Serotonin evokes the release of soluable factors from human dental pulp that increase trigeminal TRPV1 activity through a sex-dependent mechanism (Oral Presentation)


UTHSCSA Institute for Integration of Medicine and Science (IIMS) Frontiers of Translational Science Research Day - San Antonio, TX - 2015
Eskander, M., Ruparel, S., Gao, X. and Hargreaves, K. Persistent thermal allodynia triggered by nerve growth factor is mediated by TRPV1 and oxidative mechanisms (Poster)


UTHSCSA Dental Science Symposium - San Antonio, TX - 2015
Eskander, M., Sun, X. and Hargreaves, K. Serotonin evokes the release of soluble factors from human dental pulp that increase trigeminal TRPV1 activity through a sex-dependent mechanism (Poster)


Society for Neuroscience National Conference - Washington, DC - 2014
Eskander, M., Ruparel, N. and Diogenes, A. Dental stem cells of the apical papilla increase TRPA1 responses in trigeminal neurons (Poster)


UTHSCSA Pharmacology Graduate Student Symposium - San Antonio, TX - 2014
Eskander, M., Ruparel, S., Por, E., Jeske, N., Gao, X. and Hargreaves, K. Nerve growth factor-induced persistent nociception is mediated by peripheral TRPV1 activity and by oxidative mechanisms (Poster)


International Association for the Study of Pain 15th World Congress on Pain - Buenos Aires, Argentina - 2014
Eskander, M., Ruparel, S., Por, E., Jeske, N., Gao, X., Akopian, A. and Hargreaves K. Nerve growth factor-induced persistent allodynia is mediated by increased peripheral TRPV1 activity and by oxidative processes (Poster)


UTHSCSA Terry M. Mikiten Graduate Student Research Forum - San Antonio, TX - 2014
Eskander, M. and Diogenes A. Stem cells of the apical papilla increase TRPA1 responses in trigeminal neurons: implications for regenerative endodontic procedures (Oral Presentation)


UTHSCSA Center for Biomedical Neuroscience Retreat - San Antonio, TX - 2014
Eskander, M., Hargreaves, KM. and Diogenes, A. Effect of stem cells of the apical papilla on TRPA1-mediated responses in trigeminal ganglia: implications for regenerative endodontic procedures (Poster)


UTHSCSA Institute for Integration of Medicine and Science (IIMS) Frontiers of Translational Science Research Day - San Antonio, TX - 2014
Eskander, M., Ruparel, N., and Diogenes, A. Stem cells of the apical papilla increase TRPA1-mediated responses in trigeminal ganglia: implications for regenerative endodontic procedures (Poster)


UTHSCSA Dental Science Symposium - San Antonio, TX - 2014
Eskander, M., Ruparel, N., Chen, P. and Diogenes, A. Stem cells of the apical papilla increase trigeminal neuron activity: implications for regenerative endodontic procedures (Oral Presentation)


San Antonio Conference on Stem Cell Research & Regenerative Medicine - San Antonio, TX - 2014
Eskander, M., Ruparel, N., Chen, P. and Diogenes A. Stem cells of the apical papilla (SCAP) increase trigeminal neuronal activity: implications for regenerative endodontic procedures (Poster)


Society for Neuroscience National Conference - San Diego, CA - 2013
Eskander, M., Ruparel, S., Por, E., Akopian, A. and Hargreaves, K. Nerve growth factor-induced persistent allodynia is mediated by increased TRPV1 activities in rats (Poster)


UTHSCSA Pharmacology Graduate Student Symposium - San Antonio, TX - 2013
Eskander, M., Ruparel, S., Chen, P., Por, E., Jeske, N., Akopian, A. and Hargreaves K. Nerve growth factor-induced persistent thermal allodynia is mediated by increased peripheral TRPV1 activity in rats (Poster)


UTHSCSA Center for Biomedical Neuroscience Retreat - San Antonio, TX - 2013
Eskander, M., Ruparel, S., Por, E., Akopian, A. and Hargreaves, K. Increased peripheral TRPV1 activity in a rodent model of nerve growth factor-induced chronic pain (Poster)


UTHSCSA Dental Science Symposium - San Antonio, TX - 2013
Eskander, M., Ruparel, N., Chen, P. and Diogenes A. Effect of stem cells of the apical papilla on trigeminal neuronal activity: implications for regenerative endodontic procedures


Institute for Integration of Medicine and Science (IIMS) Frontiers of Translational Science Research Day - San Antonio, TX - 2013
Eskander, M., Por, E., Akopian, A. and Hargreaves, KM. Effect of nerve growth factor on peripheral TRPV1 activity and expression in a rodent model of persistent pain (Poster)


Behavior, Biology and Chemistry Conference - San Antonio, TX - 2013
Eskander, M., Ruparel, S., Green, D. and Hargreaves, KM. Central and peripheral contributions of TRPV1 to a rodent model of nerve growth factor-induced persistent pain (Poster)


UTHSCSA Cancer Therapy & Research Center Symposium - San Antonio, TX - 2012
Eskander, M., Ruparel, S., Chen, P., Green, D. and Hargreaves, KM. A rodent model of NGF-induced persistent pain: implications for cancer pain (Poster)


Society for Neuroscience National Conference - New Orleans, LA - 2012
Eskander, M., Ruparel, S., Chen, P., Akopian, A. and Hargreaves, KM. The role of nerve growth factor and oxidized linoleic acid metabolites in the transition from acute to chronic pain (Poster)


UTHSCSA Pharmacology Graduate Student Symposium - San Antonio, TX - 2012
Eskander, M., Ruparel, S., Chen, P., Green, D. and Hargreaves, KM. TRPV1 contributions to a rodent model of NGF-induced persistent pain (Poster)


UTHSCSA Center for Biomedical Neuroscience (CBN) Retreat - San Antonio, TX - 2012
Eskander, M., Ruparel, S., Chen, P., Akopian, A. Hargreaves, KM. The role of nerve growth factor and oxidized linoleic acid metabolites in a rodent model of chronic pain (Poster)


UTHSCSA Terry M. Mikiten Graduate Student Research Forum - San Antonio, TX 2012
Eskander, M., Ruparel, S., Chen, P., Akopian, A. and Hagreaves, KM. Contributions of oxidized linoleic acid metabolites to nerve growth factor induced persistent pain (Poster)


UTHSCSA Dental Science Symposium - San Antonio, TX - 2012
Eskander, M., Ruparel, S., Chen, P., Akopian, A. and Hargreaves, KM. The role of nerve growth factor and oxidized linoleic acid metabolites in a rodent model of orofacial chronic pain (Poster)


Behavior, Biology and Chemistry Conference - San Antonio, TX - 2012
Eskander, M., Ruparel, S., Chen, P., Akopian, A. and Hargreaves, KM. The role of nerve growth factor and oxidized linoleic acid metabolites in a rodent model of chronic pain (Poster)


UTHSCSA Institute for Integration of Medicine and Science (IIMS) Frontiers of Translational Science Research Day - San Antonio, TX - 2012
Eskander, M., Ruparel, S., Chen, P., Akopian, A. and Hargreaves, KM. The role of nerve growth factor and oxidized linoleic acid metabolites in the transition from acute to chronic pain (Oral Presentation)


UTHSCSA Pharmacology Graduate Student Symposium - San Antonio, TX - 2011
Eskander, M., Ruparel, S., Chen, P., Akopian, A. and Hargreaves, KM. The role of nerve growth factor and oxidized linoleic acid metabolites in the transition from acute to chronic pain (Poster)