Allison Garrison

Allison Dugan


Niles, Ohio


BS, Biology (cum laude)

Ohio State University - Columbus, Ohio

Lab Association

Jason O'Connor, Ph.D.

Hobbies and Interests

Watching movies and TV, Hanging out with friends, Shopping, Jogging, Zumba, Beginner's boxing, Listening to music, Nail art and Learning how to cook


Under inflammatory conditions, the kynurenine pathway of tryptophan metabolism in the brain is altered to produce excitotoxic metabolites and reactive nitrogen species. This aberrant up-regulation of the kynurenine pathway leads to depressive-like symptoms in mice. Microglia, the innate immune cell in the brain, may play a pivotal role in regulation of the kynurenine pathway. Allison's project focuses on understanding the relationship between kynurenine metabolites and microglial activation.

• Accomplishments, Awards and Honors •

PsychoNeuroImmunology Research Society (PNIRS) - Trainee Scholar Award - May 2017

UTHSCSA Neuroscience T32 Training Grant - 2014 - 2015

Outstanding Student Poster Presentation - 3rd Place - 2014 Center for Biomedical Neuroscience Annual Retreat - May 2014

• Appointments, Boards, Committees and Memberships •

Society for Neuroscience (SfN) - 2014 - Present

• Books and Publications •

Dugan, AM., Parrott, JM., Redus, L. and Hensler, JG. (2015). Low-level stress induces production of neuroprotective factors in wild-type but not BDNF+/- mice: interluekin-10 and kynurenic acid Int J Neuropsychopharmacol Aug 1;19(3):pyv089 doi: 10.1093/ijnp/pyv089. PMID: 26232788

Solano Fonseca, R., Mahesula, S., Apple, D., Dugan, A., Cardona, A., O’Connor, J. and Kokovay, E. (2015) Neurogenic niche microglia undergo positional remodeling and progressive activation contributing to age-associated reductions in neurogenesis Stem Cells Dev. Apr 1;25(7):542-55 PMID: 26857912

Norden, DM., Fenn, AM., Dugan, A. and Godbout, JP. (2014) TGFβ produced by IL-10 re-directed astrocytes attenuates microglial activation Glia, 62(6): 881-95

Fenn, AM., Henry, CJ., Huang, Y., Dugan, A. and Godbout, JP. (2012) Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice Brain Behav Immun., 26:(5) 766-777

• Grants, Funding and Research Support •

Neuroscience Early-Stage T32 Training Grant - 2014 - 2015

• Lectures, Posters and Presentations •

2014 Center for Biomedical Neuroscience Annual Meeting - San Antonio, TX. - May 2014

Dugan, AM., Parrot, JM., Delgado, JN. and O’Connor, JC. Neurotoxic kynurenine metabolism modulates microglia activation (Poster)

2013 Denman Undergraduate Research Forum - Columbus, OH. - March 2013

Dugan, AM., Norden, DM. and Godbout, JP. Regulation of central nervous system inflammation by TGFβ: Impairments in the aged brain? (Poster)

2012 Fall Undergraduate Research Day - Columbus, OH. - September 2012

Dugan, AM., Carroll-Turpin, MA., Mathis, JM. and Kleiner-Hancock, HE. The effects of interleukin-6 and small organic molecule on the progression of ductal carcinoma in situ (Poster)

2012 Denman Undergraduate Research Forum - Columbus, OH. - March 2012

Dugan, AM., Fenn, AM., Henry, CJ., Huang, Y. and Godbout, JP. Immune stimulus increase microglia sensitivity to interleukin-4 in adult but not aged mice (Poster)

2012 ASPET Experimental Biology Meeting - San Diego, CA. - April, 2012

Dugan, AM., Carroll-Turpin, MA., Crooks, S., Zhang, S., Mathis, JM., Kleiner-Hancock, HE. Comparison of the dietary supplement Protandim and 4-hydroxytamoxifen on pre-malignant breast cancer cell (Poster)