BS, Pharmacology and Toxicology
Minor - Forensic Science
University of the Sciences in Philadelphia - Philadelphia, Pennsylvania
Hobbies and Interests
Cooking, reading crime novels, hunting and working out
My current work is focused on natural product drug discovery for the targeted treatment of 2 types of rare cancers: triple negative breast cancer and pediatric cancer. Triple negative breast cancer accounts for approximately 15% of all breast cancer cases and is an extremely aggressive disease that disproportionately affects younger women and currently has no targeted treatments. Pediatric solid tumors have distinct etiologies compared to adult tumors and while non-targeted treatments are often curative, they leave children at an increased risk for serious complications later in life such as heart disease and secondary malignancies.
We aim to identify plant and fungal extracts with selective activity against models of these rare cancers and isolate pure compounds which may be effective targeted agents against triple negative breast cancer subtypes and/or pediatric solid tumors. Once a compound is isolated that has specific activity, we aim to determine its mechanism of action and evaluate efficacy in vivo against tumor models.
Books and Publications
Shaffer, CV., Cai, S., Peng, J., Robles, AJ., Hartley, RM, Powell, DR., Du, L., Cichewicz, RH. and Mooberry, SL. (2016) Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells J Nat Prod. Jan 19. [Epub ahead of print]