IBMS PHYSIOLOGY/PHARMACOLOGY GRADUATE STUDENTS

Corena Shaffer

 
Corena Shaffer

Hometown

Brockway, Pennsylvania


Education

BS, Pharmacology and Toxicology

Minor - Forensic Science

University of the Sciences in Philadelphia - Philadelphia, Pennsylvania


Lab Association

Susan Mooberry, Ph.D.


Hobbies and Interests

Cooking, reading crime novels, hunting and working out


Research

My current work is focused on natural product drug discovery for the targeted treatment of 2 types of rare cancers: triple negative breast cancer and pediatric cancer. Triple negative breast cancer accounts for approximately 15% of all breast cancer cases and is an extremely aggressive disease that disproportionately affects younger women and currently has no targeted treatments. Pediatric solid tumors have distinct etiologies compared to adult tumors and while non-targeted treatments are often curative, they leave children at an increased risk for serious complications later in life such as heart disease and secondary malignancies.


We aim to identify plant and fungal extracts with selective activity against models of these rare cancers and isolate pure compounds which may be effective targeted agents against triple negative breast cancer subtypes and/or pediatric solid tumors. Once a compound is isolated that has specific activity, we aim to determine its mechanism of action and evaluate efficacy in vivo against tumor models.



• Accomplishments, Awards and Honors •

American Society of Pharmacognosy Annual Meeting Student Travel Award - May 2017



• Books and Publications •

Shaffer, CV., Cai, S., Peng, J., Robles, AJ., Hartley, RM, Powell, DR., Du, L., Cichewicz, RH. and Mooberry, SL. (2016) Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells J Nat Prod. Jan 19. [Epub ahead of print]