PHARMACOLOGY POSTDOCTORAL FELLOWS
Juli Bai
 
Selected Publications

Juli Bai

Postdoctoral Fellow
Ph.D., Environmental Medicine and Toxicology
University of Shanxi
Taiyuan, China

Lab: 210-567-4526
Email: baij@uthscsa.edu
Lab Association: Feng Liu, Ph.D.

 
 

Research Interests

• adiponectin                                           • insulin
• obesity • diabetes
• insulin resistance • WAT
• BAT
 

Research Summary

Adipose tissue represents one of the major secretory organs producing a variety of factors that may regulate energy metabolism and insulin sensitivity. Adipose tissues in mammals are composed of at least two functionally different types of fat: white and brown. When dietary energy exceeds total energy needs, the energy is stored mainly as triglycerides in white adipocytes. By contrast, brown adipocytes are specialized to dissipate energy in the form of body heat. Brown adipose tissue (BAT) may play a role in protecting against obesity in humans.


Adiponectin, one of the beneficial hormones which is secreted from fat tissue, helps insulin to control blood glucose and has anti-diabetic functions. A number of studies have shown that adiponectin is an insulin sensitizer by enhancing insulin sensitivity, suggesting that the molecules in adiponectin signal pathways could be targets of therapeutic drug development for the treatment of type 2 diabetes and obesity. However, the molecular mechanism governing adiponectin action is largely unknown. DsbA-L, disulfide bond A oxidoreductase-like protein, plays a critical and selective role in regulating adiponectin biosynthesis and multimerization. It promotes adiponectin multimerization in both adipocytes and adipose tissue. Our primary interest lies in studying the molecular mechanism how DsbA-L regulates adiponectin multimerization and the consequently effect of the insulin transduction pathway and energy expenditure in both WAT and BAT. It may be contributed to the development of new therapeutic drugs for the treatment of Type 2 diabetes.

 
 

• Appointments, Boards, Committees and Memberships •

American Diabetes Association (ADA)


Chinese Society of Environmental Science (CSES)


Chinese Society of Toxicology (CST)


Shanxi Society of Toxicology (SST)



• Grants, Funding and Research Support •

Application of aptamers on detection of environmental analysis - Key Project Foundation of Ministry of Education of China (No. 2012-005) - Jan, 2013-Dec, 2015


Molecular mechanism of diabetes and cardiovascular disease induced by sulfur dioxide - Province Nature Science Foundation (No. 2010021034-1) - Jan, 2010-Dec, 2012


The association between sulfur dioxide and glucose-fatty acid metabolic disorders and its molecular mechanisms of SREBP and PPAR signal pathway - National Natural Science Foundation of China (No. 20907027) - Jan, 2010-Dec, 2012


Synthesis of novel intracellular calcium fluorescence probes and interaction of calcium signal transduction - Major Research Plan of the National Natural Science Foundation of China (No. 90813018) - Jan, 2009-Dec, 2012


Study on the expression of asthma airway hyper-responsive gene - National Natural Science Foundation of China (No. 20477023) - Jan, 2008-Dec, 2010



• Lectures and Presentations •

Bai, J., He, J., Gao, Y., Meng, Z. and Dong, C. Glucose and lipid metabolism effect by inhalation of sulfur dioxide - The 6th National Conference on Environmental Chemistry - Shanhai, China - Sep, 2011


Bai, J., He, J. and Meng, Z. Effect of sulfur dioxide on the expression of caspase-3, 8, 9 - 2010 Annual Environmental Medicine and Health branch of Chinese Society Environmental Science - Shanhai, China - Jul, 2010



• Patents •

Dong, C., Bai, J., Zhang, L., Tan, X., Qiao, J. and Li, Z. A New Method for Preparation of the Palladium Electrode - Invention Patent No. ZL200710139432.0 - The main classification number of international patent is G01N 27/30 and the proclaiming date of accrediting is August 25, 2010