David Maguire, Ph. D.
Assistant Professor/Research
Ph.D., Psychology
University of Florida
Gainesville, Florida
Lab: 210-567-4172
Email: maguired@uthscsa.edu
Research Interests
• drug abuse | • choice |
• decision making | • impulsivity |
• neuropharmacology |
Research Activities
Drug abuse remains a significant public health problem. Many factors contribute to the development and maintenance of drug taking, and an understanding of these factors will aid in the development of better prevention and treatment strategies. My research uses a variety of techniques to study the interactions between behavior and pharmacology and how those interactions impact the abuse-related effects of drugs. Current areas of interest are (1) examining effects of repeated treatment with drugs of abuse (e.g., opioids) on choice, decision making, and impulsivity and (2) evaluation of the abuse-related effects of drug combinations, particularly combinations that might have therapeutic potential (e.g., for treating pain).
Accomplishments, Awards and Honors
- NIDA Travel Award to the International Narcotics Research Conference (Bath, United Kingdom) – 2016
- ASPET Young Scientist Travel Award – 2015
- UT Health San Antonio Department of Pharmacology Chair’s Award for Excellence in Research – 2015
- ASPET Young Scientist Travel Award – 2015
- ASPET James A. Bain Young Scientist Travel Award to the World Congress of Basic and Clinical Pharmacology (Cape Town, South Africa) – 2014
- ASPET Young Scientist Travel Award – 2014
- CPDD NIDA Director’s Travel Award – 2014
- Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Training Fellow (F32) – 2013-2014
- NIDA Director’s CPDD Travel Award – 2013
- ASPET Young Scientist Travel Award – 2013
- NRSA Postdoctoral Training Fellow (T32) – 2011-2013
Appointments, Boards, Committees and Memberships
- Postdoctoral Representative, ASPET Behavioral Pharmacology Division Executive Committee, 2014-2016
- American Society for Pharmacological and Experimental Therapeutics (ASPET), Postdoctoral Member
- Association for Behavior Analysis, Member
- Behavioral Pharmacology Society
- College on Problems of Drug Dependence, Member-in-Training
- International Study Group Investigating Drugs as Reinforcers
Lectures and Presentations
- Maguire DR (2017) Exploring the therapeutic potential of opioid/cannabinoid mixtures. University of Texas Health Science Center at San Antonio, Department of Pharmacology Seminar Series.
- Maguire, DR., Weed, PF., Gerak, LR. and France, CP. (2017) Assessing therapeutic and abuse potential of opioid/cannabinoid mixtures in nonhuman primates. Winter Conference on Brain Research, Big Sky, MT.
- Maguire, DR. (2016) Exploring the link between impulsivity and drug abuse using choice procedures. Mid-American Association for Behavior Analysis, Wisconsin Dells, WI.
- Maguire, D.R. and France, C.P. (2015) Interactions between the discriminative stimulus effects of mu opioid receptor agonists and cannabinoid receptor agonists. Association for Behavior Analysis, San Antonio, TX.
- Maguire, D.R., Henson, C., and France, C.P. (2015) Effects of daily morphine treatment on impulsivity in rats responding under a 5-choice serial reaction time task. ASPET, Boston, MA.
- Maguire, D. R., Gerak, L.R. and France, C. P. (2014, February) Impulsivity and drugs of abuse. Texas Research Society on Alcoholism, San Antonio, TX.
Selected Publications
- Maguire DR and France CP (2018) Antinociceptive effects of mixtures of mu opioid receptor agonists and cannabinoid receptor agonists in rats: impact of drug and fixed-dose ratio Eur J Pharmacol Jan 15;819: 217-224. doi:10.1016/j.ejphar.2017.11.038
- Maguire DR and France CP (2016) Interactions between cannabinoid receptor agonists and mu opioid receptor agonists in rhesus monkeys discriminating fentanyl Eur J Pharmacol Aug 5;784: 199-206. PMCID: PMC4939121 doi:10.1016/j.ejphar.2016.05.018
- Lamb RJ, Maguire DR, Ginsburg BC, Pinkston JW, and France CP (2016) Determinants of choice, and vulnerability and recovery in addiction Behav Processes June;127: 35-42. PMCID: PMC4968700 doi:10.1016/j.beproc.2016.04.001
- Kangas BD and Maguire DR (2016) Drug discrimination and analysis of private events Behav Anal (Wash D C) Nov;16(4): 159-168. doi:10.1037/bar0000032
- Maguire DR, Henson C, and France CP (2016) Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task Br J Pharmacol 173: 1350-1362. PMCID: PMC4940812 doi:10.1111/bph.13434
- Selected Abstracts
- Maguire DR, Weed PF, Gerak LR, France CP (2017) Evaluation of abuse- and overdose-related effects of opioid/cannabinoid mixtures American College of Neuropsychopharmacology, Palm Springs, CA.
- Belli B, France CP, Maguire DR, Gerak LR, Bennett M, Cami-Kobeci G, Husbands SM, Flinn P (2017) OREX-1038; a potent analgesic molecule with potential for reduced abuse liability International Narcotics Research Conference, Chicago, IL.
- Belli B, France CP, Maguire DR, Gerak LR, Bennett M, Cami-Kobeci G, Husbands SM, Flinn P (2017) OREX-1019; a small molecule with potential for addiction maintenance treatment and relapse prevention International Narcotics Research Conference, Chicago, IL.
- Maguire DR and France CP (2017) Impact of delta-9-tetrahydrocannabinol on the reinforcing effects of remifentanil in rhesus monkeys responding under a food/drug choice procedure ASPET, Chicago, IL.
- Bahn AQ, Maguire DR, and France CP (2017) Morphine dose dependently restores wheel running in mice with inflammatory injury Behavior, Biology, and Chemistry, San Antonio, TX.