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Department

Pharmacology

Frazer, Alan

Chairman and Professor

Personal Statement:

My primary research interest is the mechanism of action of antidepressant drugs. Historically, the focus of my lab has been to study how chronic treatment of rats with antidepressants affects the functioning of two monoamine systems, noradrenergic and serotonergic, that are important targets for their clinical effects. More recently, our interest in treatment refractory depression caused us to study two treatments for it. One, vagal nerve stimulation, is approved by the FDA whereas the other, ketamine, is more experimental. Our studies have focused on both the mechanisms of action of these treatments and the circuits in brain necessary for their beneficial effects. The latter studies have been carried out in collaboration with Dr. Daniel Lodge in this Department, using state-of-the-art techniques such as optogenetics and designer receptors exclusively activated by designer drugs (DREADDs). A Research Instructor in my lab, Dr. Flavia Carreno (pictured below), has been the lead investigator for these studies. This work led us to study effects of selective negative allosteric modulators of α5-GABAA receptors. We found such drugs to have antidepressant-like effects similar to ketamine but not having ketamine’s adverse effect profile. Finally, in collaboration with another faculty member, Dr. David Morilak, we are studying both cognitive and emotional behaviors in animal models of depression on PTSD and the effect that antidepressant treatments and behavior therapies have on such behaviors.

 


Research

• antidepressants • norepinephrine
• serotonin transporters • vagal nerve stimulation

Affiliations

Dr. Frazer is a member of numerous societies including the American Society of Pharmacology and Experimental Therapeutics, the American College of Neuropsychopharmacology (of which he has been the President), the International College of Neuropsychopharmacology (CINP), of which he is a Councillor, and the Editor-in-Chief of their official publication, International Journal of Neuropsychopharmacology and the Society of Neuroscience. He is on the Scientific Advisory Board of the Brain and Behavior Research Foundation, which awards NARSAD grants. He has been awarded a Merit Award from NIH and has been a Career Scientist of the Department of Veterans Affairs.

Lab Members

Flavia Carreno, Ph.D. Aleeza Stephens, Graduate Student

Publications