Lodge, Daniel James

Associate Professor of Pharmacology


In a broad sense, my laboratory is interested in better understanding the mechanisms underlying psychiatric disease with the goal of developing novel therapeutic approaches. To do this we utilize a number of different approaches including optogenetics, in vivo electrophysiology, behavioral and molecular methods. Using such an approach, we have identified what we believe to be a key pathology in schizophrenia, specifically a loss of interneuron function in the ventral hippocampus. This has led to a hypothesis that restoring interneuron function may be a novel therapeutic approach for schizophrenia. Specifically, we are currently investigating the utility of stem cell derived interneuron transplants in rodent models of schizophrenia and autism.