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Department

Pharmacology

James H. Woods, Ph.D.

Research Professor

Personal Statement:

I have had an active career in research and its administration. I have led center grants, program projects, and individual projects over the course of my career, and I have participated with a variety of scientific colleagues within the University of Michigan and other universities and organizations. I have a dream of developing a drug abuse intervention pharmacotherapy that has yet to be realized. I worked on developing the enzyme CocE as an antagonist of cocaine, which went so far as clinical trials. I supported the use of mecamylamine for the treatment of nicotine abuse. MCAM and similar pseudo-irreversible mu opioid receptor antagonists are old dreams that may have a better chance of coming true, due to the extreme need for such a compound at the present time. This project should give us some much needed information about MCAM, and how useful it might be in treating one or more aspects of the opioid crisis. I look forward with considerable enthusiasm to working with the collaborators to bring this product to fruition.


Education

Ohio University, Athens, OH, B.A., 1959
University of Virginia, Charlottesville, VA, M.A., 1962
University of Virginia, Charlottesville, VA, Ph.D., 1968

Research

  • Opioids
  • Dopamine Interactions
  • Nicotinic and Muscarinic Receptors

Publications

Collins GT, Woods JH. Drug and reinforcement history as determinants of the response-maintaining effects of quinpirole in the rat.J Pharmacol Exp Ther. 2007 323:599-605

Collins GT, Truong YN, Levant B, Chen J, Wang S, Woods JH. Behavioral sensitization to cocaine in rats: evidence for temporal differences in dopamine D3 and D2 receptor sensitivity. Psychopharmacology (Berl). 2011 215:609-620.

Li SM, Collins GT, Paul NM, Grundt P, Newman AH, Xu M, Grandy DK, Woods JH, Katz JL. Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. Behav Pharmacol. 2010 21:171-81.

Bertz JW, Chen J, Woods JH. Effects of pramipexole on the acquisition of responding with opioid-conditioned reinforcement in the rat.Psychopharmacology (Berl). 2015 232:209-221.

Koffarnus MN, Collins GT, Rice KC, Chen J, Woods JH, Winger G. Self-administration of agonists selective for dopamine D2, D3, and D4 receptors by rhesus monkeys. Behav Pharmacol. 2012 23:331-338.

Patent: 2009 PCT/US2009/055169 Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same. Wang, S., Chen, J., Collins, G., Woods, J., and Levant, B. (pending).

Full List of Published Work